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In the UK, there are specific NHS criteria: Semaglutide 2.4mg (Wegovy) : NICE technology appraisal TA875 recommends this only within specialist weight management services and for a maximum of 2 years on the NHS [2] Liraglutide 3.0mg (Saxenda) : NICE technology appraisal TA664 specifies that treatment should only continue beyond 12 weeks if you've lost at least 5% of your initial body weight Clinical trials have demonstrated that most people regain weight after stopping GLP-1 medications

Canada became the first G7 country to approve a generic version of semaglutide on April 28, 2026, according to a statement from Health Canada

Both Rybelsus and Ozempic are GLP-1 receptor agonists, and using them together may increase the risk of side effects such as gastrointestinal symptoms or lower blood sugar (hypoglycemia)

Enhanced Mood and Emotional Health Low levels of B12 are linked to depression and anxiety